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What is a debilitation?

What is a debilitation? Here are some definitions.

Noun
  1. The act or process of debilitating, or the condition of one who is debilitated; weakness.
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The disease is characterised by disfiguring skin lesions, peripheral nerve damage, and progressive debilitation.
Contraries, when near and militant, will be troublesome to each other, and seek each other's destruction or debilitation.
The course of the disease varies from asymptomatic infection to extreme debilitation.
The debilitation from festering wounds and the loss of efficiency in swimming, diving, feeding and other behaviour are difficult to measure.
Minimising hazards in the physical environment is important for avoiding debilitation and painful injuries for older people.
Information regarding genetic manipulations directed toward gene inactivation, attenuation or debilitation of strains should also be outlined.

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