| Consultation with a plastic surgeon familiar with drug extravasation if local pain persists or skin changes progress after 3 to 4 days. |
| This pain is a potential warning sign of tissue damage and possible phlebitis or extravasation. |
| Even if extravasation is identified early, progressive extravasation can give rise to ulcerated and necrotic tissue over time. |
| Sealing of surgical sutures to prevent urine extravasation after construction of anastomoses in urological disorders. |
| This leads to extravasation of fibrinogen and other plasma proteins, activation of the clotting system, and deposition of a fibrin gel in the extravascular space. |
| In rare instances, extensive perivascular extravasation of CLAFORAN may result in tissue damage and require surgical treatment. |
