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What is a setback?

What is a setback? Here are some definitions.

Noun
  1. An obstacle, delay, or disadvantage.
  2. (US) The required distance between a structure and a road.
  3. (architecture) A step-like recession in a wall.
  4. (possibly archaic) A backset; a countercurrent; an eddy.
  5. A backset; a check; a repulse; a relapse.
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Examples
But he doesn't seem to be worried about the loss of earnings and career setback that most female returners experience.
The visitors refused to take this setback lying down and almost immediately forced a corner.
Scotland suffered a setback when Jones was controversially yellow-carded by Argentinian referee Manual Picara for killing the ball on the ground.
Suffering setback after setback, he is currently back in Rio recuperating from his latest.
The olive ridley turtle is one of several animal species that may have suffered a big setback as a result of last month's earthquake and tsunami.
It was an unfortunate setback after a period of relative stability and noticeable improvement.

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